OVM-100 shows compelling data for ROP vaccines as a combination therapy.
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- Seeking Series B investment for next phase of clinical trials
Call:
+44 (0) 1865 784074
Oxford Vacmedix UK Limited:
Oxford, UK, OX4 4GA
Email:
enquiries@oxfordvacmedix.com
Preclinical - exciting combination results - HPV related cancers
OVM-100
OVM-100 is an ROP vaccine targeting the cancers that can be caused by the human papillovirus (HPV). High-risk HPV types cause cancer by disrupting normal cell processes, leading to uncontrolled cell growth, and ultimately tumour formation.
Specifically, the virus's E6 and E7 proteins interfere with key cellular mechanisms, including DNA repair and cell cycle regulation, promoting genomic instability and the unrestricted development of cancer cells. HPV infections are specifically linked with cervical cancer and with about 70% of the cancers of the head and neck.
Preclinical Development
The OVM-100 ROP vaccine is in preclinical development. Preclinical results in mice have shown that even aggressive cancers can be controlled using OVM-100 alone, and that in combination with an immune-oncology agent the cancer can be completely eradicated. OVM-100 also appears to offer some protective effective from the cancer recurring. Research in the Department of Oncology at Oxford University is focused on further understanding the mechanism of action and on producing an mRNA version of OVM-100.
OVM-100: preclinical combination data
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Compelling data for Combination Therapy
The graph shows that OVM-100 alone was more effective than the IO agent in reducing the size of the tumour, but when used in combination, OVM-100 plus the IO agent, completely eliminated the tumour. The effect was sustained with follow up to 140 days. Oxford Vacmedix plans to use these exciting results to design a human clinical trial of the OVM-100 vaccine.
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