Publications Archives - Oxford Vacmedix UK

June 22, 2022 Oxford Vacmedix Comments: 0

In Vitro and In Vivo Antigen Presentation and Diagnosis Development of Recombinant Overlapping Peptides Corresponding to Mtb ESAT-6/CFP-10

The following publication describes a study developing the ROP-TB antigen for both in vitro IGRA-based TB diagnosis, as well as the in vivo skin test for TB diagnosis in both humans and cattle. The advantages of the ROP-TB diagnosis are firstly distinguishing Mtb infection from BCG vaccination, and secondly, being suitable for industrial manufacture. Read the full article: ROP-TB Diagnosis By Qing Zhang, Xiong Lu, Liang Gao, Siyu Tao, Yinghua Ge, Daocheng Cui, Renying Zhu, Wenshu Lu, Jian Wang...

May 11, 2022 Oxford Vacmedix Comments: 0

Editorial: Research, Development and Clinical Trials for Peptide-Based Vaccines

From the eradication of smallpox through to the global response to the COVID-19 pandemic, vaccines have been a cornerstone in the fight against infectious diseases in humans and livestock since the 18th century. Although vaccines against COVID-19 are unlikely to eradicate the disease in the way that the smallpox vaccine did, they have proved very effective in preventing death and hospitalisation, with enormous societal and economic benefits. There is now considerable research effort invested in...

May 11, 2022 Oxford Vacmedix Comments: 0

HPV-16 E7-Specific Cellular Immune Response

HPV-16 E7-Specific Cellular Immune Response in Women With Cervical Intraepithelial Lesion Contributes to Viral Clearance: A Cross-Sectional and Longitudinal Clinical Study High-risk human papillomavirus (HPV) infection is the cause of almost all cervical cancers. HPV16 is one of the main risk subtypes. Although screening programs have greatly reduced the prevalence of cervical cancer in developed countries, current diagnostic tests cannot predict if mild lesions may progress into invasive lesion...

May 11, 2022 Oxford Vacmedix Comments: 0

Survivin as a biological biomarker for diagnosis and therapy

Survivin (SVN) is a member of the inhibitor of apoptosis (IAP) protein family that promotes cellular proliferation and inhibits apoptosis. Overexpression of SVN is associated with autoimmune disease, hyperplasia, and tumors and can be used as a biomarker in these diseases. SVN is widely recognized as a tumor-associated antigen (TAA) and has become an important target for cancer diagnosis and treatment. Read the full article: Survivn as a biological biomarker for diagnosis and therapy By: Yuming...

Publications July 6, 2021 Oxford Vacmedix Comments: 0

Beyond Just Peptide Antigens: The complex world of peptide-based cancer vaccines

Therapeutic vaccines may well be the next wave of immunotherapy for cancer treatment. Peptide-based vaccines will play a pivotal role in the field. How is a peptide vaccine designed? What other factors such as adjuvants etc should be considered? Can Immunol oncological agents be synergetic with peptide vaccines? Read the full article: Beyond Just Peptide Antigens: The complex world of peptide-based cancer vaccines By Alexander J Stephens, Nicola A Burgess-Brown and Shisong Jiang Publisehd in Fro...